THERMO FISHER SCIENTIFIC SAFETY DATA SHEET Revision Date 14-Feb-2020 - Uses advised against Food, drug, pesticide or biocidal product use - Signal Word:Warning
qHTS assay for small molecule disruptors of the mitochondrial membrane potential (mitochondria contain two major membranes. The outer mitochondrial membrane fully surrounds the inner membrane, with a small intermembrane space in between.)
HAZARD AND PRECAUTIONARY STATEMENTS https://pubchem.ncbi.nlm.nih.gov/ghs/#_prec
Ionizable amine lipids and lipid nanoparticles-WO-2020219876-A1-The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
https://patents.google.com/patent/WO2020219876A1 Biologically active agents that are particularly difficult to deliver to cells include proteins, nucleic acid-based drugs, and derivatives thereof, particularly drugs that include relatively large oligonucleotides, such as mRNA. Compositions for delivery of promising gene editing technologies into cells, such as for delivery of CRISPR/Cas9 system components, are of particular interest (e.g., mRNA encoding a nuclease and associated guide RNA (gRNA)).
Lipid Nanoparticle Compositions
Disclosed herein are various LNP compositions for delivering biologically active agents, such as nucleic acids, e.g., mRNAs and gRNAs, including CRISPR/Cas cargoes
Nucleic acid is an important class of macromolecules found in all cells and viruses. The functions of nucleic acids have to do with the storage and expression of genetic information. https://www.genome.gov/genetics-glossary/Nucleic-Acid
7. 1,2-distearoyl-sn-glycero-3- phosphocholine, and cholesterol -DATA PFIZER VACCINE
1,2-distearoyl-sn-glycero-3-phosphocholine is a phosphatidylcholine 36:0 in which both phosphatidyl acyl groups are specified as stearoyl (octadecanoyl). It derives from an octadecanoic acid.
Thank you for your submission Diane. Nasty stuff for sure.
I am looking into the ingredients on all vaccines - this is what I have on pfizer to date from the FDA link https://www.fda.gov/media/144413/download
THE VACCINES ARE A COMBINATION OF HAZARDOUS MATERIALS AND BIOLOGICAL AGENTS
1. 4-hydroxybutyl-DATA AND FACT SHEET - PFIZER VACCINE
CAYMEN CHEMICAL - Revision: 03/23/2019
Relevant identified uses: For research use only, not for human or veterinary use
Adverse Human Health-Can cause fatal cyanide poisoning.
7 PAGES: https://www.caymanchem.com/msdss/26857m.pdf
2. azanediyl - DATA -PFIZER VACCINE
-VARIOUS CHEMICAL VENDORS
May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
https://pubchem.ncbi.nlm.nih.gov/compound/2-_3-_2-hydroxyethylamino_propylamino_ethanol
3 .hexane-6,1-diyl - DATA- PFIZER VACCINE
-Company Alfa Aesar Thermo Fisher Scientific Chemicals, Inc
THERMO FISHER SCIENTIFIC SAFETY DATA SHEET Revision Date 14-Feb-2020 - Uses advised against Food, drug, pesticide or biocidal product use - Signal Word:Warning
6 PAGES - https://www.alfa.com/en/msds/?language=EN&subformat=AGHS&sku=A12439
4. 2-hexyldecanoate -Parent Compound-CID 32912 (2-Hexyldecanoic acid) DATA-PFIZER VACCINE
qHTS assay for small molecule disruptors of the mitochondrial membrane potential (mitochondria contain two major membranes. The outer mitochondrial membrane fully surrounds the inner membrane, with a small intermembrane space in between.)
HAZARD AND PRECAUTIONARY STATEMENTS https://pubchem.ncbi.nlm.nih.gov/ghs/#_prec
https://pubchem.ncbi.nlm.nih.gov/compound/2-Hexyldecanoate
https://www.nature.com/scitable/topicpage/mitochondria-14053590/#:~:text=As%20previously%20mentioned%2C%20mitochondria%20contain,large%20as%20a%20small%20protein
5. polyethylene glycol 2000 - DATA-PFIZER VACCINE -THERMO FISHER SCIENTIFIC-SAFETY DATA SHEET
Creation Date 19-Oct-2009 Revision Date 14-Feb-2020 - COMPANY: ALPHA ASER Thermo Fisher Scientific Chemicals, Inc
Recommended Use Laboratory chemicals. Uses advised against Food, drug, pesticide or biocidal product use
Environmental Precautions Should not be released into the environment.
Other Adverse Effects The toxicological properties have not been fully investigated.
6 PAGES https://www.fishersci.com/store/msds?partNumber=AAB2218130&productDescription=POLYETHYLENE+GLYCOL+2000+250G&vendorId=VN00024248&countryCode=US&language=en
6. N-ditetradecylacetamide -DATA - PFIZER VACCINE
SEE PATENTS-
https://pubchem.ncbi.nlm.nih.gov/compound/15895653#section=Depositor-Supplied-Patent-Identifiers
Ionizable amine lipids and lipid nanoparticles-WO-2020219876-A1-The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
https://patents.google.com/patent/WO2020219876A1 Biologically active agents that are particularly difficult to deliver to cells include proteins, nucleic acid-based drugs, and derivatives thereof, particularly drugs that include relatively large oligonucleotides, such as mRNA. Compositions for delivery of promising gene editing technologies into cells, such as for delivery of CRISPR/Cas9 system components, are of particular interest (e.g., mRNA encoding a nuclease and associated guide RNA (gRNA)).
Lipid Nanoparticle Compositions
Disclosed herein are various LNP compositions for delivering biologically active agents, such as nucleic acids, e.g., mRNAs and gRNAs, including CRISPR/Cas cargoes
Nucleic acid is an important class of macromolecules found in all cells and viruses. The functions of nucleic acids have to do with the storage and expression of genetic information. https://www.genome.gov/genetics-glossary/Nucleic-Acid
7. 1,2-distearoyl-sn-glycero-3- phosphocholine, and cholesterol -DATA PFIZER VACCINE
1,2-distearoyl-sn-glycero-3-phosphocholine is a phosphatidylcholine 36:0 in which both phosphatidyl acyl groups are specified as stearoyl (octadecanoyl). It derives from an octadecanoic acid.
OCTADECANOIC ACID -
Parent Compound-CID 5281 (Stearic acid)- https://hmdb.ca/system/metabolites/msds/000/000/745/original/HMDB00827.pdf?1358895881#:~:text=Acute%20Potential%20Health%20Effects%3A%20May,May%20cause%20respiratory%20tract%20irritation.&text=Ingestion%3A%20Ingestion%20of%20large%20oral,irritation%20to%20the%20gastrointestinal%20tract.
https://pubchem.ncbi.nlm.nih.gov/compound/1_2-Distearoyl-sn-glycero-3-phosphocholine#section=Coronavirus-Studies
https://www.mdpi.com/1999-4923/13/3/377